星期日, 12月 14, 2008

Cravit 的使用注意

 clipped from 140.112.125.99
2041. Cravit dosage in patients with renal insufficiency?

Ccr 20-49 mL/min: LD 500mg, MD 250mg QD
Ccr 10-19 mL/min: LD 500mg, MD 250mg QOD

929. Cravit在HD是否會被洗掉?

Levofloxacin is not appreciably removed from the body during HD or peritoneal dialysis.

980. HEMODIALYSIS 的病人,細菌培養報告為綠膿桿菌,若使用Cravit 如何調整劑量?

HEMODIALYSIS
For the treatment of Acute Bacterial Exacerbation, Chronic Bronchitis, Community Acquired Pneumonia, Acute Bacterial Sinusitis, Uncomplicated Skin and Skin Stricture Infection, in patients undergoing hemodialysis the initial dose of levofloxacin is 500 milligrams (mg) followed by 250 mg every 48 hours (Prod Info Levaquin(R), 2005).

1125. Cravit打開之後可放多久?(已用掉半瓶)

3小時內要丟棄

1537. Cravit & Avelox oral form可否磨粉

可以,無特別規定

2514. 請問cravit F.C.的懷孕安全分級?

Cravit F.C(levofloxacin)屬於quinolone類之廣效抗生素,對於青少年期以前的動物使用,曾有發現導致軟骨生長異常的報告出現。因此盡量不要使用於青春期以前的孩童。然而對於胎兒的影響還不十分明確,動物試驗下並沒有出現致畸胎的報告,唯在高劑量下,可能導致胎兒體重降低及活動力變差,甚至死亡的情形。

48. Cravit是否會造成QT interval延長?

Yes (QT interval prolongation has been reported rarely in post-marketing reports)
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